publications

preprints / manuscripts in preparation

Border, R., Wang, J., Caggiano, C., Sankararaman, S., Schork, A.J., Turley, P., Young, A.S., Benjamin, D.J., Dahl, A.W., Zaitlen, N.. Simple models of non-random mating and environmental transmission bias standard human genetics statistical methods. 10.1101/2024.10.16.618755

Fu, B., …, Border, R., …, Sankararaman, S.. A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis. 10.1101/2023.09.10.557084

Medford, J., …, Border, R., …, Zaitlen, N.. Beyond predictive R-squared: Complex relationships between traits and their corresponding polygenic scores are revealed using non-equivalence tests of quantile-specific linear models.

Krebs, K.D., …, Border, R., …, Schork, A.J.. The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory. 10.1101/2023.06.19.23291606

Sadowski, M., …, Border, R., …, Zaitlen, N.. Genetics modulates the impact of widely-used drugs on outcomes and side effects. 10.1101/2024.03.29.24305093

Tan, T., …, Border, R., …, Young, S.. Family-GWAS reveals effects of environment and mating on genetic associations. 10.1101/2024.10.01.24314703

Wei, A., Border, R., …, Arboleda, V.. The genetic underpinnings of variable penetrance and expressivity of pathogenic mutations in cardiometabolic traits. 10.1101/2023.09.14.23295564

peer-reviewed publications

Ma, S., Wang, F., Border, R., Buxbaum, J., Zaitlen, N., Ionita-Laza, I. (2024). Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating. The American Journal of Human Genetics. 10.1016/j.ajhg.2024.10.012

Krebs, M., …, Border, R., …, Schork, A. (2024). Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression. The American Journal of Human Genetics. 10.1016/j.ajhg.2024.09.009

Romero Villela, P.N., Evans, L.M., Palviainen, T., Border, R., Kaprio, J., Palmer, R.H.C., Keller, M.C., Ehringer, M.A. (2024). Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals. Drug and Alcohol Dependence. 10.1016/j.drugalcdep.2024.111126

Dahl, A., …, Border, R., …, Cai, N. (2023). Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. Nature Genetics. 10.1038/s41588-023-01559-9

Border, R. and Malik, O.A. (2023). rBahadur: efficient simulation of structured high-dimensional genotype data with applications to assortative mating. BMC Bioinformatics. 10.1186/s12859-023-05442-6

Border, R., Athanasiadis, G., Build, A., Schork, A., Cai, N., Young, A., Werge, T., Flint, J., Kendler, K., Sankararaman, S., Dahl, A., Zaitlen, N. (2022). Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 10.1126/science.abo2059

Jami, J.S., …, Border, R., …, Middeldorp, C.M. (2022). Genome-wide association meta-analysis of childhood and adolescent internalising symptoms. Journal of the American Academy of Child and Adolescent Psychiatry. 10.1016/j.jaac.2021.11.035

Border, R., O’Rourke, S., de Candia, T., Goddard, M. E., Visscher, P. M., Yengo, L., Jones, M., Keller, M. C. (2022). Assortative mating biases marker-based heritability estimates. Nature Communications. 10.1038/s41467-022-28294-9

Ip, H.F., …, Border, R., …, Boomsma, D. (2021). Genetic association study of childhood aggression across raters, instruments and age. Translational Psychiatry. 10.1038/s41398-021-01480-x

Adjangba, C., Border, R., Romero, Villela P.N., Ehringer, M.A., Evans, L.M. (2021). Little evidence of modified genetic effect of rs16969968 on heavy smoking based on age of onset of smoking. Nicotine and Tobacco Research. 10.1093/ntr/ntaa229

Border, R. and Becker, S. (2019). Stochastic Lanczos estimation of genomic variance components for linear mixed-effects models. BMC Bioinformatics. 10.1186/s12859-019-2978-z

Border, R., Johnson, E.C., Evans, L.M., Berley, N., Sullvan, P.F., Keller, M.C. (2019). No support for historic candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples. American Journal of Psychiatry. 10.1176/appi.ajp.2018.18070881

Border, R., Johnson, E.C., Evans, L.M., Keller, M.C. (2019). Measurement error cannot account for failed replications of historic candidate gene-by-environment hypotheses: response to Vrshek-Schallhorn et al.. American Journal of Psychiatry. 10.1176/appi.ajp.2019.19040374r

Border, R., Smolen, A., Corley, R., Stallings, M., Brown, S., Conger, R., Derringer, J., Donnellan, B., Haberstick, B., Hewitt, J., Hopfer, C., Krauter, K., McQueen, M., Wall, T., Keller, M., Evans, L. (2019). Imputation of behavioral candidate gene repeat polymorphisms in 486,551 publicly-available UK Biobank individuals. European Journal of Human Genetics. 10.1038/s41431-019-0349-x

Border, R., Corley, R.C., Brown, S.A., Hewitt, J.K., Hopfer, C.J., Williams, S.K., Rhea, S., Shriver, C.L., Stallings, M.C., Wall, T.L., Woodward, K.E., Rhee, S.H. (2018). Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings, and community controls. Addiction. 10.1111/add.14366

Border, R., Corley, R.C., Brown, S.A., Hewitt, J.K., Hopfer, C.J., Stallings, M.C., Wall, T.L., Young, S.E., Rhee, S.H. (2018). Predictors of adult outcomes in clinically- and legally-referred youth with antisocial behavior. PLOS ONE. 10.1371/journal.pone.0206442

Johnson, E.C., Border, R., Melroy-Greif, W.E., de Leeuw, C., Ehringer, M.A., Keller, M.C. (2017). No evidence that schizophrenia candidate genes are more associated with schizophrenia than non-candidate genes. Biological Psychiatry. 10.1016/j.biopsych.2017.06.033

Border, R. and Keller, M.C. (2017). Fundamental problems with candidate gene-by-environment interaction studies. Journal of Child Psychology and Psychiatry. 10.1111/jcpp.12669