2025-12-22 12:00:00 -0500 EST
New work led by Morten Dybdahl Krebs examining how genotype and phenotype-based liability measures capture independent information.
The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory
Genetics has roots in studying phenotypes of relatives, but molecular approaches now facilitate direct measurements of genomic variation. We use 2,066,057 family records of 99,645 genotyped probands from the iPSYCH2015 case-cohort study to show that genotype- and phenotype-based genetic instruments explain largely independent components of liability to psychiatric disorders. Rather than one approach being superior, both methods are noisy measures of additive genetic liability that capture different information. We conclude that approaches integrating both sources of information should achieve better results for genetic research than using either method alone.